SBNeC 2010
Resumo:F.141


Poster (Painel)
F.141Unpredictable subchronic stress effects in Spatial Memory, Behavior and Corticosterone levels in High and Low Exploratory Mice
Autores:Vanessa Kaslaukcas (UFRGS - Universidade Federal do Rio Grande do Sul) ; Eduardo Kalinine (UFRGS - Universidade Federal do Rio Grande do Sul) ; Janaína Espinosa (UFRGS - Universidade Federal do Rio Grande do Sul) ; Sabrina Mioranzza (UFRGS - Universidade Federal do Rio Grande do Sul) ; Fernanda Nunes (UFRGS - Universidade Federal do Rio Grande do Sul) ; Renata Leke (UFRGS - Universidade Federal do Rio Grande do Sul) ; Lisiane Porciuncula (UFRGS - Universidade Federal do Rio Grande do Sul) ; Luis Valmor Portela (UFRGS - Universidade Federal do Rio Grande do Sul) ; Diogo Lara (PUCRS - Pontificia Universidade Catolica do Rio Grande do Sul)

Resumo

Chronic stress is a risk factor for the development of many psychopathological conditions including major depression and anxiety disorders. The aim of this study is to investigate the effect of unpredictable subchronic stress (USCS) protocol in mice selected by their exploratory behavior in the open field test (OF). We analyze the behavior effects in the open field, novel object recognition and Y-maze memory task and corticosterone levels and adrenal gland weight. Two groups of 20 mice were separated according to high or low exploration of the object to compose the high and low exploratory groups after that both groups were separated as control and stressed. After USCS protocol, low and high stressed mice showed lower exploration of the central area of the OF but locomotion did not change. In the NOR all 4 groups learned the task but the high stressed group spent less time exploring objects to learn the task and in the Y-maze test this group significantly spent more time in the novel arm. They also showed high levels of corticosterone and significant increase in the adrenal weight compared to other groups. The superior memory performance of high compared to low mice in this spatial task is consistent with our previous results but in this study we introduced the stress and even under stress conditions the high animals showed better performance.


Palavras-chave:  exploratory behavior, stress, corticosterone